Royal Air Force Typhoon fighter aircraft have operated alongside France's air force in a combined operation targeting an hidden munitions depot in Syria operated by the IS group, according to the UK's MoD.
The site, located using intelligence, was thought to be housing weapons and explosive materials, the statement said, and was situated in mountains just north of the ancient city of Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to hit a several entry passages providing entry to the facility... preliminary assessments are that the strike was effective," the MoD said.
There was no evidence of any civilian impact in the strike late on Saturday and each participating jet returned safely, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - established extremist governance over parts of both Syria and Iraq until 2019.
"This action demonstrates the UK's leading role, and commitment to work closely with our allies, to eliminate any re-emergence of Daesh and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey stated.
British military aircraft have performed overwatch operations over Syrian airspace to "prevent any attempted resurgence" of IS after its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank the personnel of our armed forces participating in this mission for their skill and their bravery," he said. "Including them were a great many British personnel deployed over Christmas and New Year. This action, to eliminate dangerous terrorists who threaten our safety, highlights how British military are always on standby, continuously, ensuring Britain's security at home and influential overseas."
In December, the American forces conducted what it termed a "major assault" against IS targets in Syria, after an attack killed two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates Islamic State still has an estimated 5,000 to 7,000 militants in both countries.
